Drug Derivatization for Enhancement of Half-Life

Some of the drugs are having very short half-life, to compensate this problem it is common practice...
¥8,394 JPY
¥8,394 JPY
SKU: 9781805450719
Product Type: Books
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Author: Gupta Vivek
Format: Paperback
Language: English
Subtotal: ¥8,394
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Drug Derivatization for Enhancement of Half-Life by Vivek, Gupta

Drug Derivatization for Enhancement of Half-Life

¥8,394

Drug Derivatization for Enhancement of Half-Life

¥8,394
Author: Gupta Vivek
Format: Paperback
Language: English

Some of the drugs are having very short half-life, to compensate this problem it is common practice to increase the dosage, frequency or prolongation of administration of drug to maintain effective therapeutic concentration in patient. In this study a drug delivery scaffold was designed and synthesized based on polyethylene glycol (PEG)- ethylene diamine tetra acetic acid (EDTA) based poly(amidoamine) (PAMAM) star polymer (with 16 primary amine group on surface). Cloxacillin, Cephalexin and Ciprofloxacin were used as a model drugs having short half life to conjugate with PEGylated dendrimer. These drugs were coupled to star polymer via ester bond. Fourier transform infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance (1 HNMR) was used to characterize the intermediate and drug-star-polymer conjugates. Invitro activity of derivatized drugs compared to standard drug alone, it was found that zone of inhibition obtained by both category of drugs (standard and derivatized drugs) are almost similar. That means drug derivatization does not altering the antibacterial activity of drugs. To investigate pharmacokinetic parameters, selected drugs alone and modified drugs [(Drug-PEG)16-Dendrimer] were intravenously injected into rats. All the modified drugs demonstrated a dramatic increase in half-life than drugs alone. These studies suggest the use of these new PEG based EDTA core dendrimer support as a valuable alternative for enhancing biological half-life of drugs.



Author: Gupta Vivek
Publisher: Independent Aurthor
Published: 11/13/2022
Pages: 242
Binding Type: Paperback
Weight: 0.72lbs
Size: 9.00h x 6.00w x 0.51d
ISBN: 9781805450719

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