The role of Rv0023 in mycobacteria tuberculosis

Tuberculosis (TB) remains a major cause of death worldwide and the leading

cause by a single infectious agent. The causative agent of

tuberculosis is Mycobacterium tuberculosis, an acid fast, non-motile, rod

shaped bacterium. The term "tuberculosis" was coined by Johann Schonlein in

1834 and Robert Koch discovered Mycobacterium tuberculosis as the causative

agent for tuberculosis in 1882. Though it was discovered in

1882, many historical evidences have estimated that the bacterium has been

present in earlier human civilizations dating back to 9000 years. Tuberculosis is

an infectious disease and is spread when an infected person coughs spreading

the bacteria in the air. The lungs are the primary target of the disease

(pulmonary TB) but it can also affect other sites such as bones, lymph nodes,

abdomen and skin (extrapulmonary TB).

Although tuberculosis occurs in every part of the world, eight countries accounted for most of the new TB cases: India,

China, Indonesia, Philippines, Pakistan, Nigeria, Bangladesh and South Africa.

The Sustainable Development Goals (SDGs) and WHO's End TB Strategy targets

to end TB epidemic by 2030 and all the United Nation member states are

committed to the cause and working closely with WHO.

The Mycobacterium tuberculosis complex (MTC) comprises of M. tuberculosis,

M. bovis, M. africanum, M. microti, M. canettii, M. caprae, and M. pinnipedii,

M. bovis and is present in a wide variety of domestic and wild animals. M.

africanum and M. canettii causes tuberculosis in humans in certain parts of

Africa. M. microti causes tuberculosis in voles, while M. caprae, and M.

pinnipedii affects mammals. All the organisms in the MTC show a great level of

similarity of more than 99% in their DNA sequences and genetic analysis of the

MTC has identified M. canettii as the ancestral strain. Despite having a high similarity, the presence of SNPs helps in discriminating between the members of the MTC.

To be a highly successful pathogen Mycobacteria has to evolve various strategies

to confront the host defence mechanisms. Most importantly its success depends

on its ability to replicate inside the macrophages, the primary host cell, and also

that the macrophages remain viable. Despite the fact that macrophages are very

effective in internalizing and clearing most of the bacteria, mycobacteria have

devised several ways to overcome these challenges.