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1. Green Synthesis of Common Heterocycles
Christian Schäfer, Hyejin Cho, and Béla Török
2. Greener Methods for Amide Bond Synthesis
Nathan J. Oldenhuis, Aaron M. Whittaker, and Vy M. Dong
3. Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications
Tsuyoshi Taniguchi
4. Direct Nucleophilic Substitution of Alcohols by Br nsted or Lewis Acids Activation: An Update
Pier Giorgio Cozzi, Andrea Gualandi, Luca Mengozzi, Elisabetta Manoni, and Claire Margaret Wilson
5. Friedel-Crafts Reactions
Grigoriy Sereda
6. Ionic Liquids: Design and Applications
Arturo Obregón-Zúñiga and Eusebio Juaristi
Part II: Synthetic Strategy
7. Designing Efficient Cascade Reactions in Drug Discovery
Chenguang Yu, He Huang, Chunquan Sheng, and Wei Wang
8. Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles
Razvan Cioc, Eelco Ruijter, and Romano V.A. Orru
9. Direct C-H Functionalization Approaches to Pharmaceutically Relevant Molecules
James J. Mousseau and Antonia F. Stepan
10. C-H Activation with Photoredox Catalysis
Joel W. Beatty and Corey R.J. Stephenson
11. In Situ Protecting Groups for Chemoselective Transformations
Alan Steven
Part III: Enabling Technologies
12. Expanding the Biocatalysis Toolbox
Rajesh Kumar, Carlos A. Martinez, and John W. Wong
13. New Directions in Coupling Chemistry
Gary M. Gallego, Rebecca A. Gallego, and Paul F. Richardson
14. Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry
Nicholas E. Leadbeater
15. Reaction Optimization: A High-Throughput Experimentation Approach
Simon Berritt and Jason R. Schmink
16. Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry
Benjamin H. Rotstein and Neil Vasdev
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