Retrotransposons and Human Disease: L1 Retrotransposons as a Source of Genetic Diversity

Thirty years ago we knew that retrotransposons made up at least half of our genomes, but little...
Dhs. 871.90 AED
Dhs. 871.90 AED
SKU: 9789811249211
Product Type: Books
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Author: Abram Gabriel
Format: Hardcover
Language: English
Subtotal: Dhs. 871.90
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Retrotransposons and Human Disease: L1 Retrotransposons as a Source of Genetic Diversity by Gabriel, Abram

Retrotransposons and Human Disease: L1 Retrotransposons as a Source of Genetic Diversity

Dhs. 871.90

Retrotransposons and Human Disease: L1 Retrotransposons as a Source of Genetic Diversity

Dhs. 871.90
Author: Abram Gabriel
Format: Hardcover
Language: English
Thirty years ago we knew that retrotransposons made up at least half of our genomes, but little about their role in biology. The human genome has since been sequenced and the position of all retrotransposons in the reference sequence has been determined. However, as of today, the function of retrotransposons still remains elusive. We know much more about the diseases associated with their movement and the host defenses we all have against them.This volume explores an array of diseases in humans associated with L1 retrotransposon movement within the human genome, including some cancers such as colon cancer and neuropsychiatric disorders such as schizophrenia.The chapters explore the diversity of retrotransposons, their different biological mechanisms, the role of L1 in their movement, and their contribution to human diseases. This book posits that somatic events caused by retrotransposons have implications for mosaicism and are often associated with cancers. Germline events are common, occur quite early in development, and are a cause of single gene diseases. All in all, the authors implicate L1 retrotransposons as major sources of human diversity and advocate for their continued study.

Author: Abram Gabriel
Publisher: World Scientific Publishing Company
Published: 09/14/2022
Pages: 300
Binding Type: Hardcover
Weight: 1.14lbs
Size: 9.00h x 6.00w x 0.63d
ISBN: 9789811249211

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