Model Systems in Biology: History, Philosophy, and Practical Concerns by Striedter, Georg

Model Systems in Biology: History, Philosophy, and Practical Concerns

How biomedical research using various animal species and in vitro cellular systems has resulted in both major...
€107,21 EUR
€107,21 EUR
SKU: 9780262046947
Product Type: Books
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Author: Georg Striedter
Format: Hardcover
Language: English
Subtotal: €107,21
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Model Systems in Biology: History, Philosophy, and Practical Concerns by Striedter, Georg

Model Systems in Biology: History, Philosophy, and Practical Concerns

€107,21

Model Systems in Biology: History, Philosophy, and Practical Concerns

€107,21
Author: Georg Striedter
Format: Hardcover
Language: English
How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.

In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this "translational" research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives--the philosophical, the historical, and that of practicing biologists.

Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models--and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a "big tent" biology, in which a diverse set of models and research strategies can coexist productively.

Author: Georg Striedter
Publisher: MIT Press
Published: 08/02/2022
Pages: 304
Binding Type: Hardcover
Weight: 1.55lbs
Size: 10.08h x 7.24w x 0.94d
ISBN: 9780262046947

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