Enough: Your Health, Your Weight, and What It's Like to Be Free

For her entire adult life, Oprah Winfrey has struggled with her weight. She never thought in her lifetime, medicines would provide hope, health, and healing for people like her. But as her conversations with Dr. Ania Jastreboff from the Yale School of Medicine reveal, we've learned that having obesity is not a choice. It's not a question of willpower.

Obesity is a disease. It's a question of biology, created by our bodies' need to survive and the environment we created and now live in. And it's treatable. The new medications can lower our body fat set point (our brain's "Enough Point"), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimize health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications. Many of her patients say the "food noise" that plagued them for years has evaporated. They describe a new freedom from intrusive, persistent, and disruptive thoughts about food. With treatment they begin a journey of healing with self-compassion, devoid of the shame and blame they've endured from society for decades. Oprah says she's learned so much from Dr. Jastreboff about how, when it comes to weight, our bodies work with us--and also against us. How each of our struggles are different and each of our choices in living with obesity may also be different. Dr. Jastreboff's groundbreaking research offers a new way forward, not only for obesity treatment, but also for overall health, with significant implications for the prevention and reversal of hundreds of related diseases. As she demonstrates in this book, when science meets empathy, real healing becomes possible. Yes, there is a path to healing and leading the life you have always wanted, when your brain is reassured that you have "enough."

Author: Oprah Winfrey,Ania M. Jastreboff
Publisher: Avid Reader Press / Simon & Schuster
Published: 01/13/2026
Pages: 288
Binding Type: Hardcover
Weight: 0.85lbs
Size: 8.61h x 5.79w x 1.01d
ISBN: 9781668217283

About the Author

As a global media leader, Oprah Winfrey has built unparalleled connections with people around the world. Through The Oprah Winfrey Show, she entertained, enlightened, and uplifted millions of viewers for twenty-five years. Her accomplishments as a philanthropist and her commitment to education have established her as one of the most respected and admired public figures today.

Ania M. Jastreboff, MD, PhD, is the Harvey and Kate Cushing Professor of Medicine (Endocrinology) and Professor of Pediatrics (Pediatric Endocrinology) at Yale School of Medicine. A compassionate physician-scientist and founding director of the Yale Obesity Research Center (Y-Weight), Dr. Jastreboff is an international thought leader in the scientific development and clinical application of novel obesity medications revolutionizing the treatment of obesity.